Faculty & Staff

Laura P. Svetkey, MD

Director of Clinical Research

Sarah W. Stedman Nutrition and Metabolism Center

Director, Duke Hypertension Center

Professor of Medicine, Division of Nephrology

svetk001@mc.duke.edu

Laura Svetkey, MD is the director of clinical research at the Sarah W. Stedman Nutrition and Metabolism Center. In this role, she brings a wealth of experience to the Stedman Center as she is also the director of the Duke Hypertension Center and has more than 20 years of experience in clinical research. She has been principal investigator on four NIH- sponsored multi-center studies on nutritional approaches to controlling hypertension and other obesity-related cardiovascular risk factors, including the landmark DASH (Dietary Approaches to Stop Hypertension) clinical trial. Currently she is principal investigator on the NIH-sponsored Weight Loss Maintenance Study and is trial-wide chair of this multi-center study of behavioral approaches to long-term weight control. Together with Dr. Christopher Newgard, Dr. Svetkey has developed and leads the STEDMAN (STudy of the Effects of Diet on Metabolism And Nutrition) Project, the flagship obesity clinical study of the Stedman Center.

Publications:

Haqq, A, Grambow SC, Muehlbauer M., Newgard CB, Svetkey LP, Carrel AL, Yanovski J, Purnell JQ, Freemark M. 2008. Ghrelin concentrations in Prader-Willi Syndrome (PWS) infants and children: changes during development. Clinical Endocrinology, in press

Lien, L.F., Haqq, A. M., Arlotto, M., Slentz, C.A., Muehlbauer, M.J., McMahon, R.L., Rochon, J., Gallup, D., Bain, J.R., Stevens, R., Ilkayeva, O., Millington, D., Butler, M.D., Newgard, C.B., Svetkey, L.P. 2008. The STEDMAN Project: Biophysical, biochemical, and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. Omics, in press

Hollis JF, Gullion CM, Stevens VJ, Brantley PJ, Appel LJ, Ard JD, Champagne CM, Dalcin A, Erlinger TP, Funk K, Laferriere D, Lin PH, Loria CM, Samuel-Hodge C, Vollmer WM, Weight Loss Maintenance Trial Research Group. 2008. Weight loss during the intensive intervention phase of the weigh-loss maintenance trial. 35: 118-126.

Ard JD, Kumanyika S, Stevens VJ, Vollmer WM, Samuel-Hodge C, Kennedy B, Gayles D, Appel LJ, Brantley PJ, Champagne C, Charleston J, Svetkey LP. 2008. Effect of goup racial composition on weight loss in African Americans. Obesity 16: 306-310.

Svetkey LP , Stevens VJ, Brantley PJ, Appel LJ, Hollis JF, Loria CM, Vollmer WM, Gullion CM, Funk K, Smith P, Samuel-Hodge C, Myers V, Lien LF, Laferriere D, Kennedy B, Jerome GJ, Heinith F, Harsha DW, Evans P, Erlinger TP, Dalcin AT, Coughlin J, Charleston J, Champagne CM, Bauck A, Ard JD, Aicher K; Weight Loss Maintenance Collaborative Research Group. 2008. Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. JAMA 299: 1139-1148.

Lien LF, Brown AJ, Ard JD, Loria C, Erlinger TP, Feldstein AC, Lin PH, Champagne CM, King AC, McGuire HL, Stevens VJ, Brantley PJ, Harsha DW, McBurnie MA, Appel LJ, Svetkey LP. 2007. Effects of PREMIER Lifestyle modifications on participants with and without the metabolic syndrome. Hypertension 50: 609-616.

Lien LF , Brown AJ, Ard JD, Loria C, Erlinger TP, Feldstein AC, Lin PH, Champagne CM, King AC, McGuire HL, Stevens VJ, Brantley PJ, Harsha DW, McBurnie MA, Appel LJ, Svetkey LP. 2007. Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndrome. Hypertension 50: 609-616.

Haqq AM, Muehlbauer M., Svetkey, L.P., Newgard, C.B., Purnell, O., Grambow , S.C. , Freemark M.S. 2007. Altered distribution of adiponectin isoforms in children with PWS: association with insulin sensitivity and circulating satiety peptide hormones. Clinical Endocrinology 67: 944-951.

Bosworth HB, Olsen MK, Dudley T, Orr M, Neary A, Harrelson M, Adams M, Svetkey LP, Dolor RJ, Oddone EZ. The Take Control of Your Blood pressure (TCYB) study: Study design and methodology. Contemp Clin Trials. 2006 Aug 16.

Elmer PJ, Obarzanek E, Vollmer WM, Simons-Morton D, Stevens VJ, Young DR, Lin PH, Champagne C, Harsha DW, Svetkey LP, Ard J, Brantley PJ, Proschan MA, Erlinger TP, Appel LJ; PREMIER Collaborative Research Group. Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial. Ann Intern Med. 2006 Apr 4;144(7):485-95.

Haqq AM, Lien LF, Boan J, Arlotto M, Slentz CA, Muehlbauer MJ, Rochon J, Gallup, D, McMahon RL, Bain JR, Stevens R, Millington D, Butler MD, Newgard CB, Svetkey LP. The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design. Contemp. Clin Trials. 2005;26(6):616-625. Epub 2005, Oct 18.

Svetkey LP, Erlinger TP, Vollmer WM, Feldstein A, Cooper LS, Appel LJ, Ard JD, Elmer PJ, Harsha D, Stevens VJ. Effect of lifestyle modifications on blood pressure by race, sex, hypertension status and age. J Human Hypertension. 2005;19:21-31.

Vollmer WM, Appel LJ, Svetkey LP, Moore TJ, Vogt TM, Conlin PR, Proschan M, Harsha D. DASH Collaborative Research Group. Comparing office-based and ambulatory blood pressure monitoring in clinical trials. J Human Hypertension. 2005;19(1):77-82.

Ard JD, Durant RD, Carter-Edwards L, Svetkey LP. Perceptions of African American Culture and Implications for Clinical Trial Design. Ethnicity and Disease. 2005;15:292-299.

Svetkey LP. Management of pre-hypertension. Hypertension. 2005;45:1056-1061.

Ard JD, Svetkey LP. Diet and blood pressure: applying the evidence to clinical practice. Am Heart J. 2005;149:804-812.

Harsha DW, Sacks FM, Obarzanek E, Svetkey LP, Lin P-H, Bray GA, Aickin M, Conlin PR, Miller ER III, Appel LJ. Effect of dietary sodium intake on blood lipids. Results from the DASH-Sodium trial. Hypertension. 2004;43:393-398.

Svetkey LP, Simmons-Morton DG, Proschan MA, Sachs FM, Conlin PR, Harsha D, Moore TJ for the DASH-Sodium Collaborative Research Group. Effect of the dietary approaches to stop hypertension (DASH) diet and reduced sodium intake on blood pressure control. J Clin Hypertension. 2004;6:373-381.

Appel LJ, Champagne CM, Harsha DW, Cooper LS, Obarzanek E, Elmer PJ, Stevens VJ, Vollmer WM, Lin P-H, Svetkey LP, Young DR. Effects of comprehensive lifestyle modification on blood pressure control: Main results of the PREMIER clinical trial. JAMA. 2003;289:2083-2093.

Sacks RM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, Obarzanek E, Conlin PR, Miller ER III, Simons-Morton DG, Karanja N, Lin P-H, for the DASH-Sodium Collaborative Research Group. Effects on blood pressure of reduced dietary sodium and the Dietary Appproaches to Stop Hypertension (DASH) diet. N Engl J Med. 2001;344:3-10.

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